Our Work
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The 生物化学 Department faculty conduct cellular and molecular research to study basic biology and the origins and treatments of human disease. 它们的目标之一是蛋白质, 疾病的代谢和遗传控制, and cell growth and differentiation in various biological systems, 包括皮肤, hair, 脂肪和感觉神经. 教员博士. Peter Agre was co-recipient of the 2003 Nobel Prize in Chemistry for his lab's discovery of aquaporin water channels. 教员与生物化学有关, 细胞和分子生物学研究生课程, the Graduate Training Program in Cellular and Molecular Medicine and the Predoctoral Training Program in Human Genetics.
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从1940年代开始, this department has applied advanced engineering technologies and concepts to biological problems and human diseases in seven research areas: engineering, 心血管系统, imaging, 系统神经科学, 分子与细胞系统, 神经工程和计算建模. The formation of the Whitaker 生物医学工程 Institute in 1999 and the faculty's close ties with the Center for Hearing and Balance, 精神/大脑研究所, the Applied Physics Laboratory and the Center for Cardiovascular Bioinformatics and Modeling encourage a multidisciplinary, 合作研究方法. 该系有自己的理学硕士学位, doctoral and postdoctoral training programs in biomedical engineering.
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The researchers in our department address fundamental biological problems at a mechanistic level, 使用包括低温电子显微镜在内的尖端工具, x射线晶体学, 核磁共振(NMR), 单分子研究和计算机建模. 目前的研究领域包括DNA复制和修复, 染色质动力学, 转录调控, 翻译, 细胞分裂, 细胞表面受体和先天免疫反应. 教师参与生物化学, 细胞和分子生物学研究生课程 and the Program in Molecular Biophysics, as well as several other 医学院 graduate programs.
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With its strong emphasis on animal models of human disease and long history of producing leaders in academic and industrial settings, this department is a national leader in research on animal diseases and animal models of human diseases. 研究课题包括艾滋病动物模型, cancer, 神经退行性疾病, 心血管疾病和炎症性肺病. Faculty, fellows and residents control disease outbreaks in the institutional animal colonies through the division of 分子与比较病理生物学 为实验动物提供临床护理 研究及动物资源科. 该部门的 逆转录病毒实验室 oversees a training grant in pathobiology for pre- and post-doctoral trainees to study the molecular pathogenesis of lentiviral diseases.
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建立在部门的长, 丰富的历史, faculty members merge molecular biology and imaging techniques to focus on cellular form, 功能与转换. Departmental scientists study topics including cell motility, division, 膜贩运, 新陈代谢, 和发展, with tools like scanning and transmission electron microscopy and scanning confocal, 全内反射, 以及点阵光片荧光显微镜. 教师参加生物化学课程, Cellular and Molecular Biology and the Johns Hopkins University Biology graduate programs.
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Department members' research projects include gene expression and regulation, 细胞周期, 信号转导, 发育生物学, 微生物发病机理, 免疫学, DNA换位, 端粒, RNA catalysis and the molecular biology of vision and olfaction. Many faculty members are Howard Hughes Medical Institute investigators. Former faculty members Hamilton Smith and the late Daniel Nathans received the 1978 Nobel Prize in 生理学 or Medicine for their discovery and use of site-specific restriction enzymes. Faculty participate in eight 医学院 graduate programs.
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神经科学 faculty focus on many areas of research including: cellular and molecular 神经科学; developmental 神经科学; neural circuits, ensembles and connectomes; systems, cognitive and computational 神经科学; and neurobiology of disease. 许多教员在其他系有联合职位. Specific research topics include the mechanisms of learning and memory, 神经递质和生长因子, 视觉系统, 突触可塑性, 电路潜在行为, 神经退行性和神经精神疾病, 神经干细胞, 前庭系统功能, 电机控制, 神经元死亡, 生存、再生和痛苦. 教师参与神经科学和生物化学, 细胞和分子生物学培训课程.
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John J. Abel, the "Father of Pharmacology," founded this department in 1893. 目前的教员都是生物化学方面的专家, 免疫学, 病毒学, cancer, 神经科学, 新陈代谢, 遗传学, 和生物物理学. 具体的研究课题包括癌症治疗, 病毒感染机制, 抗菌和抗病毒药物的开发和交付, 蛋白质结构与功能, 组蛋白乙酰化与基因调控, 药物代谢与先天免疫. Faculty accept students from the Pharmacology Graduate Training Program, 生物化学, 细胞和分子生物学研究生课程, 化学生物学接口计划, 生物化学 and Molecular Biology Training Program the Medical Scientist Training Program.
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Researchers in the Department of 生理学 integrate many disciplines to understand the functions of individual systems within a whole organism and the mechanisms that produce and sustain life. Faculty tackle issues such as the molecular control of cell membrane activities, 细胞间和细胞内的通讯, coordinated cell signaling for organ development and mammalian embryonic development. 他们使用计算方法, 遗传学 and post-genomic strategies to study these issues in a variety of organisms, 从细菌和酵母到斑马鱼, 老鼠和人. 教师参加了一些研究生课程, 包括细胞和分子生理学课程.
刘军:从自然中寻找新药
刘军博士.D., a professor of pharmacology and molecular sciences at the Johns Hopkins University 医学院, talks about the drug discovery lessons that can be learned from natural compounds, 包括免疫抑制药物FK506和雷帕霉素.
